The table and raisin grape breeding program at USDA-ARS Crop Diseases, Pests and Genetics Research Unit in Parlier, California, has been developing high-quality grape cultivars since the 1920s. Industry favorites like “Flame Seedless”, “Scarlet Royal”, and “Summer Royal” are just a few of the more than 30 cultivars that have been released by the program and are grown throughout the world. Rachel Naegele is the ARS Research Horticulturist focusing on grape breeding for durable pest resistance. Lance Cadle-Davidson’s grape research at USDA-ARS Grape Genetics Research Unit in Geneva, New York is focused on incorporating powdery mildew resistance into commercial-quality cultivars. Both USDA-ARS grape breeding programs use mapping and marker-assisted selection and collaborate with the USDA-ARS National Clonal Germplasm Repository Research Unit in Davis, California, and the USDA-ARS Horticultural Crops Research Unit in Corvallis, Oregon, on a systems approach to grape and wine production.